KMID : 1130620190150010027
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Journal of Clinical Neurology 2019 Volume.15 No. 1 p.27 ~ p.37
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Qualitative Comparison of Semantic Memory Impairment in Patients with Amnestic Mild Cognitive Impairment Based on ¥â-Amyloid Status
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Kim Ji-Eun
Park So-Hee Hong Yun-Jeong Hwang Ji-Hye Han Noh-Eul Lee Sun-Mi Roh Jee-Hoon Kim Jae-Seung Lee Jae-Hong
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Abstract
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Background and Purpose: Semantic memory remains more stable than episodic memory across the lifespan, which makes it potentially useful as a marker for distinguishing pathological aging from normal senescence. To obtain a better understanding of the transitional stage evolving into Alzheimer's dementia (AD), we focused on the amnestic mild cognitive impairment (aMCI) stage stratified based on ¥â-amyloid (A¥â) pathology.
Methods: We analyzed the raw data from Korean version of the Boston Naming Test (K-BNT) and the Controlled Oral Word Association Test (COWAT). For K-BNT, the frequencies of six error types and accuracy rates were evaluated. For a qualitative assessment of the COWAT, we computed the number of switching, number of clusters, and mean cluster size.
Results: The data from 217 participants were analyzed (53 normal controls, 66 with A¥â? aMCI, 56 with A¥â+ aMCI, and 42 disease controls). There were fewer semantically related errors and more semantically unrelated errors on the K-BNT in A¥â+ aMCI than in A¥â? aMCI, without a gross difference in the z score. We also found that A¥â+ aMCI showed a more prominent deficit in the number of clusters in the semantic fluency task [especially for animal names (living items)] than A¥â? aMCI.
Conclusions: In spite of similar clinical manifestations, A¥â+ aMCI was more similar to AD than A¥â? aMCI in terms of semantic memory disruption. Semantic memory may serve as an early indicator of brain A¥â pathology. Therefore, semantic memory dysfunction deserves more consideration in clinical practice. Longitudinal research with the follow-up data is needed.
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KEYWORD
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Alzheimer's disease, mild cognitive impairment, semantic memory, ¥â-amyloid
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